PATHOLOGY SERVICES
Histology
Our pathology core lab provides comprehensive histology services for FFPE and fresh frozen tissue samples, including specimen grossing, tissue processing, embedding and microtomy, slide staining and digitization. We produce over 35,000 slides per year on average and offer over 250 stains in our in-house library, including H&E, special stains, single and multiplex immunohistochemistry (IHC) and immunofluorescence (IF), and in situ hybridization (RNAScope® ISH).
REALM Pharma Services utilizes a CLIA certified pathology lab with robust, standardized processes that can support your research from early drug discovery all the way through to clinical trials. And for pharma partners who need a more tailored approach, we offer custom assay design to help answer novel and challenging research questions.
Staining and Biomarker Capabilities
The REALM Pharma Services team will work with you to determine which biomarkers and stains will perform best for your study. Here is just a small sampling of the biomarkers and stains we have worked with in the past, from our internal library of hundreds:
Sample Stain Types
- Alcian Blue-PAS-hematoxylin
- Bielschowsky’s Silver
- Gram Stain
- Masson’s Trichrome
- Nissl Stain
- Picrosirius Red/Van Gieson Picrofuchsins
- Toluidine Blue
- Von Kossa Stain
- Alkaline Phosphatase
- Goldner’s Trichrome
- Hematoxylin & Eosin
- Methylene Blue/Basic Fuchsin
- Periodic Acid-Schiff (PAS)
- Safranin O/Fast Green
- Tartrate-Resistant Acid Phosphatase (TRAP)
- Von Kossa Stain
- Aniline Blue
- Gomori’s Trichrome
- Luxol Fast Blue & PAS
- Movat Pentachrome
- Jones’ Stain (MPAS)
- Sirius Red
- TUNEL Stain
- Von Kossa Stain
Sample Biomarkers for Research Indications
- ONCOLOGY
- Akt
- Androgen receptor
- aSMA
- ATP-Synthase-C
- Axl
- BAK
- BCL-2
- BCL-XL
- Beta-catenin
- CA-IX
- CC3
- CD115
- CD31
- c-MYC
- Collagen 1A
- CTLA4
- Cyclin D1
- Desmin
- E-cadherin
- EGFR
- EpCAM
- Ephrin-B2
- Estrogen receptor
- FAP
- Fibronectin
- FLAG Tag
- GFP
- HA Tag
- HER2
- HH3
- HIF-1A
- HIF-2A
- HNA
- Fibroblasts
- IgG
- Mitochondrial marker
- IgG
- IgG4
- IgM
- Kappa Light Chain
- Ki67
- LAG3
- Lambda Light Chain
- LYVE1
- MCL1
- Mesothelin
- MLH1
- MLH2
- MMP9
- Myc-tag
- NGAL
- p53
- p-62
- p63
- pAkt
- pAxl
- pERK
- pHH3
- PSMA
- SLUG
- SMAD2/3
- Sodium potassium ATPase
- STAT3
- STING
- TIM3
- TROP2
- α-Tubulin
- Vimentin
- Beta-catenin
- CA-IX
- CC3
- CD115
- INFLAMMATION
- BCMA
- CCL21
- CD10
- CD11b
- CD1
- CD134
- CD137
- CD138
- CD155
- CD16
- CD163
- CD19
- CD1c
- CD20
- CD200
- CD206
- CD21
- CD24
- CD27
- CD3
- CD33
- CD335
- CD39
- CD3ε
- CD4
- CD44
- CD45
- CD45RO
- CD56
- CD68
- CD69
- CD73
- CD8
- CD8a
- Cdh11
- cGAS
- CK pan+
- Dendritic cell marker
- F4/80
- FoxP3
- Galectin
- GITR
- Granzyme B
- ICOS
- ITGA3
- LAMP1
- OX40
- PD-1
- PDGFRa
- PD-L1
- SIRPa
- STING
- SYK
- TIGIT
- CD40L
- CD134
- CD137
- CD138
- CD155
- CD16
- NEUROSCIENCE
- Anti-
neutrophil - APC
- Ataxin-2
- beta-Amyloid
- CHAT
- GFAP
- GPR17
- IBA1
- Myelin basic protein
- OLIG-2
- pcJUN
- Phospho-tau
- pp38
- pPRAS40
- Proteolipid protein
- SIRPb
- SMI
- tSYK
- Tyrosine hydroxylase
- beta-Amyloid
Contact Us
Discover how REALM Pathology Services can help
accelerate your drug development.
Pioneering integrated diagnostics for a new realm of understanding.